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The duration effect suggests GHK-Cu induces cumulative structural changes in dermal architecture where longer treatment allows more complete remodeling supporting ongoing enhanced function without continuous peptide presence

The speciation of metal at different times following in vivo exposure shows that cadmium, mercury initially form low-MW metal conjugates with glutathione, from which the metal is later transferred to MT

Free Radic Res (2004) 38:65964

Szelenyi) 301317 (Birkhuser Basel, 1993)

[DOI] [PubMed] [Google Scholar] Zarrindast MR, Khakpai F (2015) The modulatory role of dopamine in anxiety-like behavior

Annu Rev Nutr (2015) 35:10934