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The UT-A1 and UT-A3 transporters are critical for urea reabsorption during antidiuresis in order to maintain the hypertonic state of the medullary interstitium (anatomically the spaces between the tubule cells and the endothelial cells of the blood vessels)

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Combined triad-GSH metabolism model simulations: quinone metabolism and ROS production Following the parameterisation and sensitivity analysis, the triad model was expanded to include GS-H 2 Q adduct formation (quinone removal) and was combined with the glutathione metabolism model constructed by Reed et al

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In patients with type 2 diabetes, the background incidence is higher, ranging from 11.4 to 82 per 100,000 person-years