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TB-family peptides investigated for cytoskeletal remodeling and angiogenesis in cardiac ischemia models

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Mitochondrial dysfunction and DNA damage : Dysregulation of the NAD/PARP1/SIRT1 axis and mitochondrial injury promotes fibrogenesis and hepatocyte dysfunction [131, 132]

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In rapidly proliferating tissues (bone marrow and some neoplastic tissues), the PPP directs its metabolites toward nucleotide synthesis, providing necessary precursors for DNA and RNA synthesis, thus meeting the requirements of cell proliferation

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