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For assessment of glucose-induced insulin secretion, glucose was given orally at a dose of 4 g kg 1 in 6 h fasted mice, followed by blood sampling at timepoints 0, 2, 5, 15 and 30 min after glucose administration

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Understanding realistic weight loss timelines helps you stay motivated and track whether your treatment is working effectively

Ethical/regulatory aspects Given the novelty, informed consent must emphasise off-label / investigational status

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Constipation is more common in weight loss patients (24%) than diabetes patients and may worsen with higher doses