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In our study, the fatty acid composition in cholesteryl esters of VLDL + LDL particle changes in favor of a decay in the content of saturated C16 and an enhancement in the level of diunsaturated C18 leading to a 3-fold reduction of the saturated to unsaturated ratio of those animals supplemented with L-carnitine (group 4 vs 3)

Roughly comparable GI profiles

Notably, compared to the use of GIPR antibodies alone or control antibody-GLP-1 conjugates, GIPR-Ab/GLP-1 exhibits a more potent weight-reducing effect, suggesting a synergistic interaction between the two targeting mechanisms

In some cases, slowing the titration schedule under medical supervision can meaningfully reduce side-effect burden without compromising therapeutic benefit