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Baseline glutathione status: If your glutathione is severely depleted (from chronic stress, illness, poor diet, or age), rebuilding takes longer

In addition, mitochondria are also the primary producers of intracellular reactive oxygen species (ROS), most of which originate from the mitochondrial respiratory chain [55]

For instance, a 2-year study on mesenchymal stem cells for knee osteoarthritis noted significant clinical improvements at one and two months, but also saw a deterioration in some metrics by the two-year mark

it depends on your levels

Such a change was also found in healthy individuals which showed reduction of DNA methylation in individuals with the TT MTHFR genotype compared to subjects with CC MTHFR 29

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