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In one of these studies, it was reported that more than 80% of the structures refined at a resolution lower than 1.75 contain at least one missing string and about 20% of the structures refined at a resolution better than 0.75 contain at least one missing string (Djinovic-Carugo and Carugo, 2015)

doi: 10.2147/DMSO.S209095 54 SergiDNaumovskiNHeilbronnLKAbeywardenaMOCallaghanNLionettiLet al

The fragmentation, in other words, is genuine, tirzepatide wins on a different axis, but it is not a clean upgrade across the board

Liu et al., 2013)