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Its metabolic benefits, such as increased energy expenditure, are secondary to its effects on neurotransmitters like norepinephrine in the brain

Oxidative stress as a second line of attack occurs after the onset of initial pathology, documented, for example, by the formation of superoxide radicals and hydrogen peroxide by NADPH oxidases, for example, in the response to injury-mediated inflammation

People taking metformin and tirzepatide together may experience compounded GI effects that require extra attention to hydration