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In a 5-year study of 521 stable CKD patients, plasma TMAO levels increased over time, and long-term dietary TMAO intake directly associated with renal fibrosis and dysfunction progression (137)

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GLP-1RAs act on overlapping hypothalamic circuits, reducing appetite and improving energy balance and have been shown to promote browning of white adipose tissue, contributing to increased energy expenditure

Inflammation induces the up-regulation of ROS and can cause overt OS, resulting in tissue injury and subsequent preterm labor [249]

[DOI] [Google Scholar] Romero F., Espliego F., Perez Baz J., Garcia de Quesada T., Gravalos D., de la Calle F., Fernandez-Puentes J

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