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Because HPA-axis dysregulation is implicated in numerous stress-related conditions, compounds capable of restoring healthy neuroendocrine regulation have attracted considerable scientific interest

doi:10.1002/ohn.1209

Medicines and Healthcare products Regulatory Agency , 'MHRA approves GLP 1 receptor agonist semaglutide to reduce risk of serious heart problems in obese or overweight adults', July 2024

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Second, confirm that you have no recent opioid exposure or active opioid dependence, which would contraindicate naltrexone