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Excess glucose drives mitochondrial reactive oxygen species (ROS) overproduction and oxidative stress, which can disrupt intracellular trafficking and impair the delivery of OCTN2 to the plasma membrane [112]

Notably, dexamethasone, a potent corticosteroid, was ineffective in restoring normal epidermal morphology in the same study

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With proper lip care, avoiding triggers, or medical treatments like creams or laser, the natural lip colour may slowly improve, but results may not be the same for everyone 4