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The sequence incorporates an -aminoisobutyric acid (Aib) residue at position 2 for DPP-4 protease resistance, along with a C20 fatty diacid moiety attached via a hydrophilic linker at lysine-26, enabling albumin binding and extended half-life in preclinical plasma studies

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Consistently, clinical and preclinical OA studies indicated a cumulative oxidative burden in osteoarthritic chondrocytes 39,40

These may occur with or without pain, and, as with other injection site reactions, usually go away on their own within a few days

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No significant side effects were reported, apart from abdominal discomfort and diarrhea (which was attributed to a high daily dose of magnesium) [78] (Table 2)