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Materials and methods Ethics statement All animal studies were carried out in accordance of the UK Animals (Scientific Procedures) Act 1986 under a UK Home Office project license

J Clin Endocrinol Metab (2001) 86(1):6671

[1] [2] Unlike sulfonylureas or insulin, metformin does not typically cause hypoglycemia when used as monotherapy, making it a preferred initial pharmacologic option for most patients with type 2 diabetes

Roth, J.R., J.G

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Harnessing glucagon-like peptide-1 receptor agonists for the pharmacological treatment of overweight and obesity