glp-1 vagus nerve Increasing GLP‐1 Circulating Levels by Bariatric Surgery or by GLP‐1 Receptor Agonists Therapy: Why Are the Clinical Consequences so Different? - Amouyal - 2016 - Journal of Diabetes Research Neural effects of gut‐ and

Naltrexone, primarily known as an opioid antagonist, plays a role in reducing food cravings by blocking certain receptors in the brains reward pathway. This helps to diminish the pleasurable feelings associated with eating, which can be particularly beneficial for individuals who experience emotional or reward-driven eating

Implications for precision medicine Mutations or loss of CD36 may contribute to reduced PROTAC efficacy or resistance

doi:10.1136/jcp.42.6.624

Case reports and small observational studies describe some patients on semaglutide or tirzepatide reporting reduced alcohol cravings or consumption, but no large randomized controlled trial has tested this as a primary outcome

PMID: 17 YeshiKJamtshoTWangchukP

Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJM, Gavaghan DJ, et al