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The receptor question is itself contentious: integrin V5 has been proposed as a functional receptor mediating irisin effects on bone and adipose tissue, and V3 integrin has been implicated in neuroprotective effects, yet neither has been universally accepted as a bona fide irisin receptor, and the binding affinities reported vary across experimental systems (Kim et al., 2018

These favorable effects may contribute to the observed survival benefits in patients with type 2 diabetes and concomitant AKD

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As GLP-1 induced cutaneous reactions are diverse, diagnosis requires clinical suspicion, thorough history-taking, and supportive histopathological findings when available