Dihexa or its analogs were administered 5 minutes after scopolamine, either intracerebroventricularly at doses of 0.1 or 1 nmol), intraperitoneally at doses of 0.05, 0.25, or 0.50 mg/kg, or orally at doses of 1.25 or 2.0 mg/kg
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The animals underwent a sciatic nerve repair model that began with the transection of the main sciatic nerve above the trifurcation point into the tibial, fibular, and sural branches
Key Research Compound Highlights DIHEXA (N-hexanoyl-Tyr-Ile-(6)-aminohexanoic amide): A synthetic small-peptide analog of hepatocyte growth factor (HGF) designed to cross the blood-brain barrier
The parent compound, Nle-AngIV, demonstrated an exceedingly short half-life of less than 2 minutes
