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Realistic expectations are 0.25-0.5 kg (0.5-1 lb) per week under optimal conditions, with the rate influenced by baseline body composition, dietary habits, activity level, and individual metabolic responsiveness

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One rat treated with exenatide died of pancreatic necrosis, and other animals had findings of acinar-to-ductal metaplasia and foci of ductal hyperplasia, which were interpreted as premalignant changes 6,7

Sutalangka C, Wattanathorn J (2017) Neuroprotective and cognitive-enhancing effects of the combined extract of Cyperus rotundus and Zingiber officinale