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Additionally, melatonin significantly reduced the number of NFTs and attenuated neuronal loss in the cortex and hippocampus [115]

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In individuals with nutritional deficiencies (e.g., strict vegetarians without supplements), injections may be given less frequently or replaced by oral supplements once levels stabilize

Therefore, to eliminate the potential baseline effect of different studies, the rates of body weight change from the initial values were selected as the therapeutic index, which was a better indicator used to assess changes in body weight