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An initial pilot study showed that supplementation of children with autistic disorder with 800 g folinic acid and 1,000 g betaine per day for two months normalised homocysteine levels and improved GSH:GSSG [46]

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In the REDEFINE 1 trial, published in the New England Journal of Medicine, participants receiving the combination achieved 20.4% mean body weight reduction at 68 weeks

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DeTure MA, Dickson DW (2019) The neuropathological diagnosis of Alzheimers disease