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These effects generally indicate either starting doses too high or individual sensitivity

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Alsaqati M, Heine VM, Harwood AJ

Furthermore, the AlphaFold2 structure recreates clearly visible cryo-EM density for almost the entirety of the R-domain residues 883897 and 849860, excluding ~20 residues

Mitochondrial ROS can cause HMGB1 translocation and secretion