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The translation from mouse to human senolytic therapy has proven challenging for several reasons: species differences in senescent cell biology

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This is to be expected as these cells are already expressing hTERT mRNA, moreover, in the normal cells, epitalon would have to initiate hTERT expression, presumably by promoter activation

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10.1016/s0014-2999(97)01033-9 81 StambolijaV.StambolijaT