GLP-1 Receptor Agonists and the Thyroid: C-Cell Effects in Mice are Mediated via the GLP-1 Receptor and Not Associated With RET Activation
The MHRA has dismantled UK-based illicit manufacturing operations producing fake retatrutide and tirzepatide pens, and counterfeit products have been found to contain the wrong dose, the wrong drug, or contaminants
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The most robust evidence to date comes from a phase 2 randomised controlled trial (Jastreboff et al., New England Journal of Medicine , 2023), in which retatrutide was evaluated over 48 weeks in adults with obesity but without type 2 diabetes
This triple-agonist mechanism has been extensively documented in peer-reviewed literature for its interaction with metabolic signaling pathways and receptor cross-talk