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Like CaMKK2, the PKA signalling pathway is also considered to play a key role in the pathogenesis of bipolar disorder, as increased cyclic AMP levels and PKA activity have been frequently observed in post-mortem brains and peripheral cells of bipolar disorder patients [58,59,60,61]
Dalle-Donne I
Moreover, improved hepatocyte ballooning and steatosis, inhibited inflammatory pathways, mitophagy-mediated active pyroptosis were noticed with liraglutide use in patients with NAFLD [35,36,37]
As obesity management became a priority, healthcare providers increasingly opted for high-dose regimens to meet patient expectations and clinical goals
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