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The adipose tissue triglyceride lipase ATGL/PNPLA2 is downregulated by insulin and TNF-alpha in 3T3-L1 adipocytes and is a target for transactivation by PPAR

It also modulates intracellular calcium, reducing abnormal neurotransmitter release and inflammation

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During the treatment of RA, NPs, GLP-1RAs@NPs or GLP-1RAs@NPs-WYRGRL were injected subcutaneously into the skin of the hind paws of rats, or MN and MN/GLP-1RAs@NPs-WYRGRL were used to puncture the skin and left in place

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