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A large phase 3 trial with hard endpoints and long follow-up is a far stronger basis for clinical decisions than a phase 2 signal, however impressive that signal is
Whilst this combination of two very different chemical regions within a single moiety enhances the medical utility, it can make the bioanalysis extremely challenging
We are working on the hybrid synthesis, where we make some [peptide] pieces with SPPS and then we will couple [them] together with an enzyme. So far they have done this for liraglutide using a unique ligation point the site where the enzyme couples two natural amino acids
Comparison of the effects of various C-terminal and N-terminal fragment peptides of glucagon-like peptide-1 on insulin and glucagon release from the isolated perfused rat pancreas
Risks include nausea, digestive discomfort, and potential hormonal side effects