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Front Nutr 9:853058 Fgc LN, Carneiro BA, Alves GS, Lins Silva DH, Faria Guimaraes D, Souza LS, Bandeira ID, Beanes G, Miranda Scippa A, Quarantini LC (2022) Metabolomics of major depressive disorder: a systematic review of clinical studies

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By resisting binding to IGF-binding proteins (IGFBPs), IGF-1 LR3 remains free in the bloodstream longer, which increases its ability to activate IGF-1 receptors in muscle tissue