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Head-to-head comparison table No direct head-to-head trial between tirzepatide and retatrutide exists yet

Retatrutide brought it down by around 2 percentage points at higher doses

Normally, if someone overeats, they would feel nauseous, which is a helpful signal from the body that you consumed more food than needed, says Haley Singer, RD

Your provider can distinguish tirzepatide-related reflux from cardiac issues, gallbladder problems (which blood work can help evaluate), esophageal spasm, or other conditions that might mimic heartburn

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