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The SURMOUNT-1 trial, also published in the New England Journal of Medicine, found that participants lost an average of 16.0% of body weight at the 5mg dose, 21.4% at 10mg, and 22.5% at the highest 15mg dose over 72 weeks, compared to 2.4% in the placebo group with 89% to 96% of participants (depending on dose) reaching at least 5% weight loss

While these suggest a favorable profile at moderate doses, large-scale human clinical trials haven't been conducted

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