Further research is needed to confirm causality, identify high risk groups, and guide monitoring strategies
Collectively, these limitations underscore the need for longer-term clinical studies, human-based mechanistic investigations, and well-designed comparative analyses to more fully validate the therapeutic potential and optimize the clinical application of GLP-1RAs in liver diseases
2A and E, due to insulin resistance, the ratio of islet area to pancreatic area was increased by HFD, on the contrary, semaglutide or calorie restriction decreased the ratio of islet areas
What to do: Include resistance exercise in your weekly routine Eat enough high-quality protein throughout the day Work with a dietitian to support muscle preservation during weight loss 2
302 : E666E673
New England Journal of Medicine , 381 (26), 2541-2551