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The Lancet (2023) 6

10.1155/2019/8563845 Oxid Med Cell Longev

The concentration of GSH that is normally about 400 M in the epithelial lining fluid, over a 100-fold higher than in plasma, is low in the airways of patients with cystic fibrosis from an early age (112114)

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The role played by GSH in these defense systems cannot be overstated

Modules correlated with the KO genotype were enriched for neuronal and synaptic genes involved in vesicle-mediated transport, neurotransmitter secretion, and GTPase activity, suggesting that RAMP deletion disrupts synaptic signaling networks critical for metabolic regulation [2]