You're a strong candidate for B12 injections if you experience any of the following: Persistent fatigue that sleep doesn't fix Brain fog, forgetfulness, or trouble concentrating Low mood, anxiety, or stress that feels disproportionate to what's happening Weight gain or difficulty losing weight despite consistent effort Tingling, numbness, or weakness in hands or feet (signs of B12-related neuropathy) Frequent colds, slow healing, or post-COVID fatigue A plant-based, vegetarian, or vegan diet Age 50 or older (B12 absorption naturally declines with age) A history of gastric bypass, Crohn's disease, celiac disease, or chronic acid reflux Long-term use of metformin (for diabetes), proton pump inhibitors (Prilosec, Nexium), or H2 blockers (Pepcid, Zantac) An MTHFR gene variant or known methylation issue A history of B12 deficiency, pernicious anemia, or low folate Hormonal shifts: perimenopause, menopause, postpartum If you fit one or more of these, a vitamin B12 shot is one of the lowest-risk, fastest-acting interventions available
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Science Writers Seminar in Ophthalmology: Research to Prevent Blindness
, 25 , 4787-4792, doi: Han, C., Liu, Y., Dai, R., Ismail, N., Su, W., and Li, B
CR and DL have distinct effects on mTORC1 signaling and autophagy mTORC1 signaling has been extensively studied in the brains from AD mouse models, revealing mTORC1 activation in these brains 25,26
There are currently no human clinical trials showing that BPC-157 treats anxiety or depression
