The active site of the enzyme that binds glycine to the dipeptide -L-glutamyl-L-cysteine is highly specific (57)
[6] [3] [10] A mild deficiency may not cause any discernible symptoms, but moderate deficiency can cause various symptoms, such as feeling tired, lightheadedness, headaches, cold intolerance, pale skin, sore tongue, upset stomach, loss of appetite, hair and skin color changes, numbness or tingling (pins and needles) of the fingers and toes, and tinnitus, and vision, cognitive or psychological problems
Only Wegovy has received FDA approval for a medical condition in addition to chronic weight management 7
Additionally, phospholipase C plays an important role in the inflammation pathway
Many are trying to address this by expanding their range of protein-rich products and creating GLP-1 companion products, but it probably wont be enough
Always start at the lower end of the dose range and titrate based on bowel response