Full story via BioPharma Dive: #ClinicalTrials #DrugDevelopment #AIDrugDiscovery #SmallMolecules #Immunology #Neuroscience #BiopharmaInnovation #ClinicalResearch #LifeSciences #PrecisionMedicine To view or add a comment, sign in Zealand Pharma + OTR Therapeutics partner on metabolic disease therapeutics with $20M upfront + $2.5B biobucks - more biotech & pharma news below: Amgen's Uplizna (inebilizumab) wins FDA approval for generalized myasthenia gravis targeting CD19-positive B cells xcellbio + Culture Biosciences partner to advance cell therapy quality through AI and machine learning Eli Lilly and Company's retatrutide (triple hormone receptor agonist) achieves 26.6% weight loss in Ph3 obesity trial Aukera Therapeutics emerges from stealth with CHF 4.5M ($5.63M) funding for neurological RAPTOR inhibitor development ProLynx raises $70M Series A for longer-lasting obesity drugs with less frequent dosing European legislators agree on major pharma policy overhaul reducing drug exclusivity periods + strengthening supply chains For all the news, check out the full (free) TLDR Biotech newsletter here: ---------------------------------------- One skimmable email per day to keep up with biotech and pharma Sponsored today by Science 2 Sales - outsourced lead generation services hyperfocused on biotech and life sciences

This triple-hit strategy implies that retatrutide might work swifter or superior for certain individuals
The Diabetes Control and Complications Trial Research Group (1998) Early worsening of diabetic retinopathy in the diabetes control and complications trial

Women should contact their GP or specialist if they develop severe or persistent symptoms potentially related to oestrogen changes, including: Significant worsening of menopausal symptoms (hot flushes, night sweats, mood changes) Vaginal dryness or discomfort affecting quality of life Unexplained changes in libido or sexual function Symptoms suggestive of bone health concerns (unexplained fractures, significant height loss) Mood disturbances or depressive symptoms Seek urgent medical attention if you experience: Severe, persistent abdominal pain (especially radiating to the back) with or without vomiting, which could indicate pancreatitis Upper right abdominal pain, fever, or yellowing of the skin/eyes, which might suggest gallbladder disease Signs of dehydration (extreme thirst, dry mouth, reduced urination, dizziness) Suspected pregnancy while taking semaglutide Routine monitoring during semaglutide treatment should follow NICE guidance for diabetes management or weight management programmes

What Research Shows About Effects Based on clinical trial data from FDA-approved brand-name medications: Appetite effects: GLP-1 medications act on brain receptors that influence hunger and satiety signals
E.Beas-ZrateC.Nuez-LumbrerasM