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The result is 100% bioavailability at therapeutic concentrations that oral supplementation cannot reliably achieve

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& Seong, J

[12] The oral upper intake levels established for dietary copper do not translate directly to a copper-carrying peptide delivered subcutaneously, which bypasses the intestinal regulation of copper absorption entirely one more reason the systemic dosing of GHK-Cu is genuinely uncharacterized in humans

Out-of-spec pH, endotoxin load, or non-pharmaceutical particulates in the water create conditions that destabilize the peptide's tertiary structure, causing aggregation and visible haze

doi: 10.3389/fphar.2019.01327 [DOI] [PMC free article] [PubMed] [Google Scholar] 26.Tallarida RJ