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Disease states can affect both of the physiologically related primary pharmacokinetic parameters: volume of distribution and clearance

Most current research-context subcutaneous protocols cite 300-500 mcg/day, but no published human pharmacokinetic study has formally evaluated the subcutaneous route

List cellular mechanisms: inflammation modulation, fibroblast ECM output, oxidative stress reduction, and glycation changes

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Li Y, Glotfelty EJ, Karlsson T, Fortuno LV, Harvey BK, Greig NH

Understanding why a compounding pharmacy might add B12, and how compounded formulations are regulated, explains where this formulation fits