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Mechanistically, there is no established biological pathway by which semaglutide would directly damage pancreatic tissue

Under oxidative stress, metabolic reprogramming may influence cellular survival and ferroptosis susceptibility (Suzuki et al., 2022), Gln also modulates iron homeostasis by regulating its uptake and storage, thereby indirectly controlling iron overload risks

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[1] [8] This mechanism underlies strict warnings that MB should not be administered alongside selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), certain tricyclic antidepressants, or other MAO inhibitors, except in life-threatening situations

doi:10.1530/EJE-14-0147 Adlin V