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A good letter makes a straightforward argument

Between September and October 2024, adults aged 18 years or older who had used a GLP-1RA for at least a month were recruited

Weve all experienced this sensation at one point or another, whether after eating something that didnt agree with us or when we contracted a stomach flu

GLP-1 Up works with your body, not against it

The second is neural, where GLP-1 activates vagal nerve afferents in the gut wall that transmit satiety signals directly to the nucleus tractus solitarius (NTS) in the brainstem