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The observed differences appear to be dependent on the animal model, as previous studies have shown that MitoQ is well tolerated at concentrations up to 500 M in drinking water over several weeks, without causing adverse effects on behavior or metabolism (57, 83)

Details regarding parameter values, including inter-individual, inter-occasion and residual variability, are provided in Table 1 of the Electronic Supplementary Material (ESM)

Nielsen KK, Kromann-Andersen B, Steven K et al: Failure of combined supratrigonal cystectomy and mainz ileocecocystoplasty in intractable interstitial cystitis: Is histology and mast cell count a reliable predictor for the outcome of surgery

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TLR-4 is a key mediator of innate immune activation, activated by gut-derived LPS, leading to an exaggerated inflammatory response

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