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Thus, 23 (HA08) stabilizes the closed conformation of IRAP

GLP-1 helps regulate appetite, slows digestion, and improves insulin response

In patients with hypothalamic obesity, those peripheral signals arrive at a hypothalamus that cannot act on them, because the MC4R pathway downstream of -MSH is silenced

The mitochondrial isoform, GOT2, operates with GOT1 as part of the MalateAspartate shuttle, which is required to shuttle electrons into the mitochondria for use in the ETC and to restore NAD + pools required for glycolytic flux (Son et al, 2013)