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However, the direct answer is no

Kalk, Stephen J

Because calorie intake is extremely low, many patients experience rapid weight loss within a short period of time

Theoretical concerns: Because DSIP interacts with the opioid system and ACTH axis in animal models, chronic use could theoretically affect neuroendocrine regulation

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Additional information Supplementary Information accompanies the paper on the The Pharmacogenomics Journal website Appendix PREDICT investigator group: Argentina: A Belgorosky, Buenos Aires