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Wadden T, Bailey TS, Billings LK, et al

Increased intracellular Ca2+ concentrations trigger fusion of insulin-containing granules with the plasma membrane and insulin secretion from the cells

The first of these drugs, exenatide, was approved by the FDA in 2005

Nausea most likely in this phase

Although no significant differences were found among the groups in total hip and femoral neck aBMD or trabecular bone score (TBS), changes in lumbar spine aBMD approached statistical significance