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People with obesity have higher baseline levels of GLP-1 but less variability, especially if they also have metabolic syndrome or diabetes

Senescent chondrocytes accumulate in osteoarthritic joints, contributing to inflammation and tissue breakdown via the senescence-associated secretory phenotype (SASP)

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Circulating hormone levels are typically far lower than those produced by medications, but the system functions as a coordinated regulatory network rather than a single dominant signal

Patients with genetic markers indicating high nausea susceptibility may benefit from slower titration schedules or pre-planned anti-nausea support, whereas those with low-risk profiles often tolerate standard protocols comfortably