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Early research suggests that GIP receptor activation might have different effects on the microbiome than GLP-1 activation alone

Their hypothesis is that the physiological peak of melatonin produced at night may compensate for the decreased melatonin production by extra-pineal tissues during the daytime, which occurs during AD onset episodes (108)

Adjustment: Some individuals start with a lower dose (250500 mcg) to test tolerance before increasing

doi: 10.1016/j.biopha.2023.114586 87 LohseM

Metformin can lead to a vitamin B12 deficiency, so your doctor should test for that every year

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