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What is the TRIUMPH Phase 3 trial
Both the glutamine-induced inward current and the calcium transient were mimicked using 10 mmol/l asparagine and abolished by extracellular sodium removal
18 They found that patients taking semaglutide were more likely to develop NAION at two, three and four years after initiation of treatment, with a cumulative HR of 2.22 after four years compared to control (n=45 vs 29)
As with the skin work, the framing in published reviews remains observational with respect to mechanism, and most authors note that the in vivo translation outside of topical and injected animal-model contexts is not fully characterized
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