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A 2015 Cell Metabolism study that first characterized MOTS-c as a mitochondria-derived regulator of metabolic homeostasis capable of reducing obesity and insulin resistance in animal models was foundational in establishing this peptide class

These approaches can help bridge the gap between theoretical aspirations and practical implementation, fostering a more inclusive and resilient urban future

Park CH, Abramson ZR, Taba M Jr, et al

Weight-loss percentages and adverse events from a trial cannot be converted into evidence of improved skin firmness

XL: Writingreview and editing, Resources, Methodology, Formal Analysis, Conceptualization

In this Review, we discuss common reasons for GLP1R agonist and tirzepatide discontinuation and examine available evidence related to potential cardiometabolic consequences