In the STEP and SURMOUNT trials: Constipation was reported in up to 24% of patients on semaglutide 18-23% of patients on tirzepatide experienced constipation It is one of the top three side effects of these medications and is more frequent in those who: Lose weight rapidly Eat low-fiber diets Are female (due to hormonal factors affecting gut motility) Conventional Treatment Approaches Most providers recommend over-the-counter (OTC) remedies such as: Stool softeners (docusate) Fiber supplements (psyllium, methylcellulose) Laxatives (PEG 3350, senna, Mag Citrate) These can help in the short term but do not address the root cause
Although we cannot prove that this patient generated new neurons or synapses, our results using this combination of therapies (TPE with 5% albumin replacement, peptides, and UCT-MSc-EXs) are truly promising
Apr 21st, 2026 How GHK-Cu Benefits Skin & Hair GHK-Cu is a copper-binding peptide with promising roles in skin regeneration and tissue repair, but its broader medical use is limited by insufficient human data, regulatory restrictions, and an incompletely defined safety profile
Ahmed S, Ghazarian MP, Cabanillas ME, Zafereo ME , Williams MD, Vu T, Schomer DF, Debnam JM
Most reputable vendors ship with appropriate packaging to minimize temperature excursions
10.1016/j.bmc.2006.09.014 103
