468 used a conjugate of the cytoplasmically localized internalized peptide (CLIP6) and PNA to treat GBM cells, considerably upregulating the tumor suppressor Mnk2a and promoting cancer cell death
The historical significance of methylene blue extends beyond its initial synthesis, as its applications have evolved and expanded over the years
This interaction promotes the dissociation of the KEAP1-NRF2 complex, preventing NRF2 ubiquitination and degradation, thereby enhancing NRF2 expression
In addition, dual incretin agonists (e.g., GIP/GLP-1 co-agonists such as tirzepatide) have expanded this therapeutic space, while other long-acting or multi-agonist candidates remain investigational (14)
Copper peptides naturally turn blue when mixed with water and exposed to oxygen
That's where the magic happens