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The 600% increase in GLP-1 usage from 2019 to 2024 reflects both the medications' effectiveness and the urgent need for obesity treatments ^18

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Statistical analyses Data were analysed using R (v.4.3.2) for sequencing data and Prism (v.9.0) for statistical significance of all other data

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To overcome these limitations, future research must prioritize the development of open-source benchmark datasets, domain adaptation algorithms, and hybrid models that integrate imaging data with molecular readouts