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4,5 With aging, however, this tightly regulated balance becomes disrupted

The clinical proof of concept comes from CagriSema, the combination of cagrilintide with semaglutide

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Preclinical studies, small controlled trials, and observational research further suggest that GLP-1 receptor agonists may have beneficial effects in the prevention and treatment of mood disorders and in psychopathology domains that substantially impair quality of life, including cognitive dysfunction and anhedonia