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PLoS Genet 10 , e1004354 (2014)

centrally-mediated loss of appetite & increased thermogenic activity GLP-1 receptors are found in regions of the hindbrain and hypothalamus that regulate feeding behavior Centrally mediated GLP-1 effects include: reduction of food intake - resulting in weight loss due to reduced caloric intake activation of sympathetic pathways in the dorsomedial hypothalamus (DMH) and ventromedial nucleus of the hypothalamus (VMH) that increase neuronally mediated thermogenic activity of brown adipose tissue (BAT) resulting in increased energy expenditure with associated weight loss (Contreras et al, 2017

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Hydration, Electrolytes, and Nutrient Needs During Therapy Semaglutide reduces overall food volume, which can inadvertently lower sodium, potassium, and magnesium intake

Metformin preconditioning of human induced pluripotent stem cell-derived neural stem cells promotes their engraftment and improves post-stroke regeneration and Recovery

Ning et al